Chemical Hypothyroidism - By Dr. Oscar Vargas-Machuca E. MD

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Chemical Hypothyroidism

By Dr. Oscar Vargas-Machuca E. MD - 1991

When people started to consume Alen, some years ago, a curious phenomenon was noticed. A group of patients, who were a little obese lost weight, another group stayed the same. These two groups made up the 75%. However, a third group (25 %) gained weight.

This paradoxical answer to a strictly alimentary substance awakens our interest and we decided to find out the reason for this. After a research lasting about a year, we established the principal cause; it was the hormone called reversed triiodinethyroxine that was present in the patients who gained weight.

This strange phenomenon is very important for public health since medicine considers that only one person out of ten thousand suffers from this disorder. Our research discovered that the actual proportion is impressively high and it should be taken into account in order to avoid such abundant chemical hypothyroidism. Our result coincides with statistics of the International Health Organization, which establishes that 25% the human beings are sickly, to which we could add that they also have chemical hypothyroidism.

Reversed triiodinethyroxine (RT3) is isomeric with triiodinethyronine (T3) but the former has lost 80% its hormonal activity. People who have it in a higher percent display chemical hypothyroidism, which should not be confused with glandular hypothyroidism. In the disorder in question the thyroid gland does not present any anomaly and its interaction with the hypophysis is correct.

The thyroid produces two thirds of hormone T4 and one third, of hormone T3, which is active unlike T4 that has to suffer a modification of its iodine atoms. This is done in the liver, kidney and other tissues where hormone T4 must be converted into T3 via enzymatic action. A number of hardly known factors allow the production of a T3 isomer; T3 loses a iodine atom located in the in the front part of the molecule originating reversed L-triiodinethyronine (RT3) which as we already said, is not functional.

The organic disorders contributing to this anomaly can be: fasting, hyperinsulinism, stress and non-thyroid critical diseases, on account of the presence of the hormone somatostatine, a peptid that in inhibits secretion of TSH (Thyroid Stimulant Hormone) other conditions such as diabetes, obesity, arteriosclerosis, arthritis, consumption diseases and premature aging. In these disorders there is a movement from T4 into T3 into RT3 which results in a reduced activity of thyroxine. This phenomenon can be interpreted as an homeostatic defense mechanism and is carried out with the purpose of reducing the catabolic activity of the thyroid hormone when the organic tissues should be preserved.

Considering the problem from the biochemical point of view, it comes down to an anomalous subtraction of the iodine atom of hormone T4, where an iodine atom from the second benzene, carbon 5 is lost. The resulting isomer presents great stability in the bond of the iodine atoms of the first benzene, carbon 3 5, which do not tend to chemical combinations. The opposite happens when the thyroxine has the iodine atoms linked to carbons 3 5 and 3 the active thyroxine (T3).

The interatomic blockade occurring in iodine atoms 3, 5 is responsible for the existence of a reversed isomer (RT3), which brings about that the hormone receivers and transporters cannot properly recognize it in order to transport the energetic molecules. Therefore it causes a reduction of combustion (unknown mechanism) and a delay in the RNA function. However, somatic manifestations are obvious as if it were a latent hypothyroidism unlike glandular hypothyroidism.

The symptoms of this disorder are general organic deficiency; weight gain and adiposity accumulation caused by water retention with unclear oedemas weight gain in the evenings, slight loss of immunologic defenses, disorders of fat and glucide metabolism, increase of arteriosclerosis, dysfunction of the collagen tissue as well as premature aging.

Those patients have normal results in tests on the biochemical and functional equilibrium between the hypophysis and the thyroid, unlike radioimmunoassays, whose results reflect an increased RT3 which can originate mistakes in the medical diagnosis of patients who do not present an evident thyroid dysfunction.

When a person having chemical hypothyroidism takes Alen he/she begins to gain weight on account of both fat reserve and water retention. This has been interpreted as a reaction of adaptation to the metabolic changes caused by Alen in an organism partially lacking the essential factors. When those patients take in the nutritional elements they need, the thermodynamic chain of transformation improves due to the recuperation of its enzymatic potential that was reduced before, on account of hypermetabolism. With Alen, the poor metabolism equilibrium moves towards an anabolism gradient which demands a greater supply of thyroxine T4 and T3; since most of the thyroxine is reversed, chemical hypothyroidism appears.

The experience with Alen gave us the possibility of discovering an anomalous group of patients representing 25% of the normal individuals in our studied universe.

Some researchers suspect that the rise of reverted T3 is genetically conditioned. We believe that the phenomenon is probably two-sided, 1) acquired from diabetic inheritance, obesity, arthritis and arteriosclerosis, 2) related to the increase of sugar intake in contemporary diets. We had the possibility of finding in our country human groups relatively isolated from civilization out in our territories, who have quite natural alimentary habits and do not consume sugar; we did not find reversed T3 in them.

An easy method to know if we have an excess amount of RT3 is weighing ourselves morning and night. If we find a person more than 2 pounds overweight, we can determine that we suffer from this disorder.

Another important consideration is that we noticed that people who have RT3 are more unhealthy than the average population. All in all, we can say that this group includes all the patients that for different reasons go to private practice offices, clinics and hospitals, and also those who most frequently suffer from degenerative, involute, and even proliferative diseases.

This information is quite relevant for public health since we can obtain many social and sanitary advantages from the study of this human group.

To control this problem, patients should take from 25 mcgr. to 12 mcgr. of L--triiodinethyronine a day so as to stimulate the production of a correct T3 hormone by means of a comparative process. We consider the stimulation must happen in this way because a very low dosage is enough to correct the anomaly, without any interference in the relationship thyroid-hypophysis.

Unfortunately, throughout our research we have not been able to see the reversal of this disorder in adults (although we suspect it is acquired), unlike children and youths up to 30 years of age. Here we have seen a high rate of normalization after one or two months taking T3, when hormonal conditions return to their equilibrium, especially if the patient follows the guidelines of holistic medicine.